When is the best time to come out once you have accepted it yourself?

I have finally quit the denying to myself and have accepted that I am only attracted to women but my family isn't the most open minded do you guys think its better to let them know and get it over with or is there a certain time or place in time that it should be done.. one thing I am tired of is my mother asking "why don't you give this guy a chance?" "or this one or that one?" How are you supposed to tell her " I have no interest with being with a male period." I guess I just kept being in denial because I didn't want to face this part of telling my family especially my grandparents for those of you who are out how do you suggest I do this?