Greetings, This is a very important development in pre-exposure prophylaxis clinical research: taking just one pill "on-demand" just before a sexual act is protective! Study finds PrEP successful at protecting against HIV when taken just before sex · PinkNews.co.uk Here is the significance of this: when a recommendation is announced, mid-trial, to change placebo treatment to an actual treatment, it is because the positive interim results are so compelling that it would be unethical to continue having subjects on the placebo treatment.