In general:Are there any? For fictional shows: Are there any played by trans men? And do they have leading or supporting roles?
I couldn't think of any, but Wikipedia could! List of transgender characters in film and television - Wikipedia, the free encyclopedia
Top FTM Characters in Popular Movies and TV Programs here is a link about the top 5 ftm TV and movie characters
The only one I can think of is Cole on the Fosters, who's played by a trans man (Tom Phelan). He's a fairly minor character though.